Re: [escepticos] ¿Infiltraciones de ozono para dolor de espalda?

[Ramon Diaz-Alersi]

Perdón, este debí haberlo enviado en primer lugar:

Spine (Phila Pa 1976). 2009 Jun 1;34(13):1337-44. Intramuscular oxygen-ozone
therapy in the treatment of acute back pain with lumbar disc herniation: a
multicenter, randomized, double-blind, clinical trial of active and
simulated lumbar paravertebral injection. Paoloni M, Di Sante L, Cacchio A,
Apuzzo D, Marotta S, Razzano M, Franzini M, Santilli V. Physical Medicine
and Rehabilitation Unit, Azienda Policlinico Umberto I, Rome, Italy.
paolonim en tin.it
STUDY DESIGN: Multicenter randomized, double-blind, simulated
therapy-controlled trial in a cohort of patients with acute low back pain
(LBP) due to lumbar disc herniation (LDH).
OBJECTIVE: To assess the benefit of intramuscular-paravertebral injections
of an oxygen-ozone (O2O3) mixture.
SUMMARY OF BACKGROUND DATA: Recent findings have shown that O2O3 therapy can
be used to treat LDH that fails to respond to conservative management.
However, these findings are based on intradiscal/intraforaminal O2O3
injection, whereas intramuscular-paravertebral injection is the technique
used most in clinical practice in Italy and other Western countries.
 METHODS: Sixty patients suffering from acute LBP caused by LDH was
randomized to an intramuscular O2O3 or control group. Patients were observed
up to assess pain intensity, LBP-related disability, and drug intake (15
[V2] and 30 [V3] days after treatment started, and 2 weeks [V4], and 3 [V5]
and 6 [V6] months after treatment ended).
RESULTS: A significant difference between the 2 groups in the percentage of
cases who had become pain-free (61% vs. 33%, P < 0.05) was observed at V6.
Patients who received O2O3 had a lower mean pain score than patients who
received simulated therapy throughout the observation period. A significant
improvement was observed in LBP-related disability in the study group
patients when compared with the control group patients. Active O2O3 therapy
was followed by a significantly lower number of days on nonsteroidal
anti-inflammatory drugs at V2 and V3 and by a lower number of days at V4. No
adverse events were reported.
CONCLUSION: Treatment of LBP and sciatica is a major concern. Although the
natural history of acute LBP is often self-limiting, conservative therapies
are not always effective; in such cases, O2O3 intramuscular lumbar
paravertebral injections, which are minimally invasive, seem to safely and
effectively relieve pain, as well as reduce both disability and the intake
of analgesic drugs.

Saludos.

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Ramón Díaz-Alersi