[escepticos] El SIDA fue creado en un laboratorio.
JM Mulet
jmmulet en ibmcp.upv.es
Jue Nov 19 13:10:50 WET 2009
Las primeras muestras de sangre con virus del sida datan del año 1959, por
lo que la tecnología del ADN recombinante, necesaria para producir o
modificar un virus en el laboratorio, no estaba todavía desarrollada.
Aquí te paso una referencia reciente sobre el origen del SIDA:
Nature. 2008 Oct 2;455(7213):661-4.
Direct evidence of extensive diversity of HIV-1 in Kinshasa by 1960.
Worobey M, Gemmel M, Teuwen DE, Haselkorn T, Kunstman K, Bunce M, Muyembe
JJ, Kabongo JM, Kalengayi RM, Van Marck E, Gilbert MT, Wolinsky SM.
Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona
85721, USA. worobey en email.arizona.edu
Comment in:
Nature. 2008 Oct 2;455(7213):605-6.
Human immunodeficiency virus type 1 (HIV-1) sequences that pre-date the
recognition of AIDS are critical to defining the time of origin and the
timescale of virus evolution. A viral sequence from 1959 (ZR59) is the
oldest known HIV-1 infection. Other historically documented sequences,
important calibration points to convert evolutionary distance into time, are
lacking, however; ZR59 is the only one sampled before 1976. Here we report
the amplification and characterization of viral sequences from a
Bouin's-fixed paraffin-embedded lymph node biopsy specimen obtained in 1960
from an adult female in Léopoldville, Belgian Congo (now Kinshasa,
Democratic Republic of the Congo (DRC)), and we use them to conduct the
first comparative evolutionary genetic study of early pre-AIDS epidemic
HIV-1 group M viruses. Phylogenetic analyses position this viral sequence
(DRC60) closest to the ancestral node of subtype A (excluding A2). Relaxed
molecular clock analyses incorporating DRC60 and ZR59 date the most recent
common ancestor of the M group to near the beginning of the twentieth
century. The sizeable genetic distance between DRC60 and ZR59 directly
demonstrates that diversification of HIV-1 in west-central Africa occurred
long before the recognized AIDS pandemic. The recovery of viral gene
sequences from decades-old paraffin-embedded tissues opens the door to a
detailed palaeovirological investigation of the evolutionary history of
HIV-1 that is not accessible by other methods.
PMID: 18833279 [PubMed - indexed for MEDLINE]
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